Research Articles
Small Molecule Inhibitors for Dendritic Cell Generation from Bone Marrow: Mechanisms, Methods, and Therapeutic Applications
This comprehensive review explores the innovative use of small molecule inhibitors to generate and mature dendritic cells (DCs) from bone marrow precursors, a rapidly advancing field in cancer immunotherapy and...
High-Throughput Flow Cytometry Immunophenotyping of Human Blood: A Comprehensive Guide for Robust Pipeline Design and Execution
This article provides a comprehensive guide for researchers and drug development professionals on implementing high-throughput flow cytometry for deep immunophenotyping of human blood.
Optimizing Antibody Validation for Flow Cytometry: A Complete Guide to Robust and Reproducible Results
This article provides researchers, scientists, and drug development professionals with a comprehensive framework for optimizing antibody validation specifically for flow cytometry applications.
A Comprehensive Guide to Handling Batch Effects in Single-Cell RNA-Seq Data Preprocessing
This article provides researchers, scientists, and drug development professionals with a complete framework for managing batch effects in single-cell RNA sequencing data.
Standardizing Immunology: Protocols and Quality Control for Reproducible Data in Research and Drug Development
Reproducibility in immunological data is fundamental for robust scientific discovery and successful translational research.
Computational Frontiers in Single-Cell Immune Repertoire Analysis: From Data to Clinical Insights
Single-cell immune repertoire analysis has transformed our understanding of adaptive immunity by enabling high-resolution profiling of T-cell and B-cell receptor sequences at the individual cell level.
Deep Learning in Immunotherapy: Predicting Antibody Affinity and TCR Binding for Accelerated Drug Discovery
This article explores the transformative role of deep learning (DL) in predicting antibody-antigen affinity and T-cell receptor (TCR)-peptide-MHC binding, two critical interactions in immunotherapy development.
Microfluidic Platforms for Modeling Vascular Inflammation: A Comprehensive Guide to TEER Measurements and Applications
This article provides researchers, scientists, and drug development professionals with a comprehensive overview of microfluidic platforms for modeling vascular inflammation, with a focus on Transendothelial Electrical Resistance (TEER) as a...
Generating Functionally Active Adipose Tissue-Resident Macrophages Using 3D Culture Systems: A Protocol and Review
This article provides a comprehensive resource for researchers and drug development professionals on the generation and application of functionally active adipose tissue-resident macrophages using advanced 3D culture systems.
A Comprehensive Guide to MiXCR: Mastering Immune Repertoire Analysis for Research and Drug Development
This article provides a comprehensive guide to MiXCR, a powerful computational tool for immune repertoire analysis.